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Anti-Mullerian Hormone

Test Codes

Mayo: AMH1, EPIC: LAB7039, Beaker: XAMH

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube. 

Physician Office/Draw Specimen Preparation

Let specimen clot completely then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.1 mL)

Rejection Criteria

• Gross hemolysis
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot completely then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.1 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 90 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Monday, Wednesday, Friday.
Results available in 2-5 days.

Reference Range

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA).

Interpretation

While the optimal AMH concentrations for predicting response to in vitro fertilization are still being established, it is accepted that AMH concentrations in the perimenopausal to menopausal range indicate minimal to absent ovarian reserve. Depending on patient age, ovarian stimulation is likely to fail in such patients By contrast, if serum AMH concentrations exceed 3 ng/mL, hyper-response to ovarian stimulation may result. For these patients, a minimal stimulation would be recommended.

In patients with polycystic ovarian syndrome, AMH concentrations may be 2- to 5-fold higher than age-appropriate reference range values. Such high levels predict anovulatory and irregular cycles.

In children with intersex conditions, an AMH result above the normal female range is predictive of the presence of testicular tissue, while an undetectable value suggests its absence.

In boys with cryptorchidism, a measurable AMH concentration is predictive of undescended testes.

Granulosa cell tumors of the ovary may secrete AMH. Levels should fall with successful treatment. Rising levels indicate tumor recurrence or progression.

AMH measurement alone is seldom sufficient for diagnosis and results should be interpreted in light of clinical findings and other relevant test results.

Clinical Utility

• Assessment of ovarian function.
• Is part of the workup for infertility.
• Assessment of intersex conditions.
• Evaluation for polycystic ovarian syndrome.

CPT Codes

83520
LOINC:  83104-0

Contacts

Last Updated

7/2/2021