Benzodiazepine Screen, Urine
Urine Benzodiazepines Screen, Valium, Librium, Xanax, Ativan, Tranxene, Serax, Halcion, Benzodiazepines Screen, Urine
Test Codes
Antrim #17081, EPIC: LAB7010, SOFT: BENZZ
Department
Chemistry
Specimen Collection Criteria
Collect: 50 mL random urine in a screw-capped container (preferred) or other sterile collection cup with no preservative. (Minimum: 30 mL)
- Refrigerate the specimen immediately after collection.
- Record the exact time of specimen collection on the container or in the computer system.
Physician Office/Draw Specimen Preparation
Maintain specimen refrigerated (2-8°C or 36-46°F) prior to transport.
Preparation for Courier Transport
Transport: 50 mL urine, refrigerated (2-8°C or 36-46°F). (Minimum: 30 mL)
Rejection Criteria
- Specimens not collected and processed as indicated.
- Urine Vacutainer® tubes. Urine received in a glass or plastic tube with a rubber stopper may contain insufficient sample volume, preclude confirmatory testing, and give rise to contaminants and artifacts.
In-Lab Processing
Analyze specimen immediately upon receipt in the Laboratory.
Storage
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months
Specimen Storage in Department Prior to Disposal:
Refrigerated (2-8°C or 36-46°F): 7 days
Laboratory
Canton Chemistry Laboratory
Dearborn Chemistry Laboratory
Farmington Hills Chemistry Laboratory
Grosse Pointe Chemistry Laboratory
Lenox Main Laboratory
Livonia Main Laboratory
Royal Oak Automated Chemistry Laboratory
Troy Chemistry Laboratory
Taylor Chemistry Laboratory
Trenton Chemistry Laboratory
Wayne Chemistry Laboratory
NOTE: Screens are performed at Canton, Dearborn, Farmington Hills, Grosse Pointe, Royal Oak, Taylor, Trenton, Troy and Wayne. All confirmations are performed at Royal Oak Toxicology Laboratory.
Performed
Sunday – Saturday, 24 hours a day.
STAT results (screen) available within 1 hour of receipt in the Laboratory, confirmation within 36 hours. Routine results available within 48 hours.
Reference Range
Negative.
Positive cutoff: 200 ng/mL.
Test Methodology
Screen: Enzyme Immunoassay.
Confirmation: Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS).
Note: Confirmation performed at Royal Oak only.
The confirmation component of this test was developed by Beaumont Health. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.
Interpretation
Most of the Benzodiazepines will react with the reagents in the screening procedure. Metabolites will also react and add to the sensitivity of the testing.
Clinical Utility
This assay is used to aid in the diagnosis and treatment of benzodiazepine use or abuse. This assay provides a preliminary analytical result. Positive results are confirmed by chromatographic methods. Benzodiazepines are central nervous system depressants composed of over 20 compounds. They are used clinically as sedatives, hypnotics, anxiolytics, muscle relaxants, antiepileptics, and in the treatment of alcohol withdrawal. Benzodiazepines are extensively metabolized with half-lives ranging from 1 to 100 hours. Urine levels vary due to each patient's metabolic and excretion rates.
CPT Codes
80307, 80347 (alternate: G0479, G0480).
LOINC: 70142-5, 46976-7
Contacts
Main Laboratory – LVA
947-523-4370
Name: Main Laboratory – LVA
Location:
Phone: 947-523-4370
Main Laboratory – LNX
947-523-4070
Name: Main Laboratory – LNX
Location:
Phone: 947-523-4070
Toxicology Laboratory – RO
248-551-8058
Name: Toxicology Laboratory – RO
Location:
Phone: 248-551-8058
Automated Chemistry Laboratory – RO
248-551-8065
Name: Automated Chemistry Laboratory – RO
Location:
Phone: 248-551-8065
Chemistry Laboratory – TRN
734-671-3165
Name: Chemistry Laboratory – TRN
Location:
Phone: 734-671-3165
Chemistry Laboratory – DBN
313-596-2196
Name: Chemistry Laboratory – DBN
Location:
Phone: 313-596-2196
Chemistry Laboratory – TYL
313-295-5360
Name: Chemistry Laboratory – TYL
Location:
Phone: 313-295-5360
Main Laboratory –WYN
734-467-4274
Name: Main Laboratory –WYN
Location:
Phone: 734-467-4274
Canton Laboratory
734-454-8024
Name: Canton Laboratory
Location:
Phone: 734-454-8024
Chemistry Laboratory – FH
947-521-5252
Name: Chemistry Laboratory – FH
Location:
Phone: 947-521-5252
Chemistry Laboratory – TR
248-964-8070
Name: Chemistry Laboratory – TR
Location:
Phone: 248-964-8070
Chemistry Laboratory – GP
313-473-1807
Name: Chemistry Laboratory – GP
Location:
Phone: 313-473-1807
Last Updated
5/18/2022
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