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Chlorpromazine Level

Thorazine, Ormazine, Largactil

Test Codes

ARUP #90870, EPIC: LAB5974, SOFT: XCPL

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavender-top EDTA tube.

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to next dose.

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 2.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Rejection Criteria

Serum Separator (SST) Tube.

Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 2.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 12 hours
Refrigerated (2-8°C or 36-46°F): 72 hours
Frozen (-20°C/-4°F or below): 5 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Wednesday, Saturday.
Results available in 2-6 days.

Reference Range

Adult (12 Years and Older) Therapeutic: 50-300 ng/mL.
Adult Toxic: Greater than 750 ng/mL.

Child (0 - 11 Years) Therapeutic: 30-80 ng/mL.
Child Toxic: Greater than 200 ng/mL.

Test Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry.

Interpretation

By report.

Clinical Utility

Chlorpromazine is used to treat psychotic disorders (e.g., schizophrenia), control nausea and vomiting, relieve restlessness prior to surgery, treat acute intermittent porphyria, control the manic phase in bipolar disorders, to treat intractable hiccups, and treat problems in children characterized by hyper-excitable, aggressive stages. This assay is used for the therapeutic monitoring and toxicity assessment of Chlorpromazine.

CPT Codes

80342 (alternate code: G0480).
LOINC:  3471-0

Contacts

Last Updated

7/7/2021