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Mumps IgG

Mumps Virus Antibody, IgG

Test Codes

EPIC: LAB6897, SOFT: MUMPS

Department

Special Chemistry

Specimen Collection Criteria

Collect: One Gold-top SST tube. (Minimum Whole Blood: 2.0 mL)

Physician Office/Draw Specimen Preparation

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL)

Rejection Criteria

Plasma specimens. 

Severely lipemic, icteric, or hemolyzed specimens.    

  

In-Lab Processing

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Room temperature is acceptable for a maximum of two hours. (Minimum Serum: 0.5 mL)

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers^® with Separator Gel
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers^® without Separator Gel
Room Temperature (20-25°C or 68-77°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory

Performed

Tuesday – Saturday.
Results available within 3 business days.

Reference Range

Less than or equal to 8.9 AU/mL: Negative – No significant level of detectable mumps virus antibody.
9.0-10.9 AU/mL: Equivocal - Repeat testing in 10-14 days may be helpful.
Greater than or equal to 11.0 AU/mL: Positive – IgG antibody to mumps virus detected which may indicate a current or previous exposure/immunization to mumps virus. Positive IgG antibody levels in the absence of current clinical symptoms may indicate immunity.

Test Methodology

Chemiluminescent Immunoassay.

Interpretation

IgG is first detectable 7-10 days after the onset of symptoms. Once present IgG levels remain detectable for the lifetime of the patient. Eighty to ninety percent of adults have antibody to mumps virus (1).

Clinical Utility

This assay aids in the diagnosis of a recent infection or immunity due to vaccine or previous exposure.

Clinical Disease

Once transmitted, the mumps virus can produce symptomatic and asymptomatic infections. Typical mumps is an acute, self-limiting disease characterized by bilateral or unilateral parotitis. However, mumps virus infections can sometimes cause meningoencephalitis, orchitis, ovaritis, pancreatits, thyroiditis, or infections of the eye or inner ear (1).

Epidemiology

Mumps is endemic throughout the world. Prior to licensing of the live attenuated mumps vaccine, epidemics occurred every 2-5 years with the peak incidence occurring from January through May. In the prevaccine era, more than 50% of cases occurred in the 5-to 9-year group and 90% of disease occurred in children under 14 years of age. Today, more than 50% of mumps cases occur in teenagers and young adults. There is only one serotype of mumps virus (1).

Incubation Period

The incubation period is 16-18 days with a range of 2-4 weeks. Patients are infectious from 9 days prior, to 8 days after, the development of parotitis. Urine from mumps patients should be considered infectious for two weeks after onset of symptoms (1).

Transmission

Mumps is transmitted by direct contact and through inhalation of infectious aerosols. In addition, the virus can be spread indirectly by autoinoculation of the nose or mouth after handling infected fomites, soiled handkerchiefs, or tissues (1).

Reference

1. Wiedbrauk D, Johnston SLG. Manual of Clinical Virology, Raven Press, New York, NY, 1993.

CPT Codes

86735
LOINC: 25418-5

Contacts

Last Updated

6/14/2021