Laboratory Lab results are too important to go anywhere else.

Cytomegalovirus Antiviral Drug Resistance by Sequencing

CMV, CMV Resistance, UL54, UL97

Test Codes

ARUP: 2004760, EPIC: LAB7591, Beaker: XCMVRG

Department

Send Outs

Instructions

This test requires the Cytomegalovirus (CMV) DNA Quantitation by PCR to have a result of at least 1500 copies/mL.

Specimen Collection Criteria

Collect: Two Lavender-top EDTA tubes.

Physician Office/Draw Specimen Preparation

Centrifuge to separate plasma from cells within 8 hours of collection. Transfer plasma to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 4.0 mL serum or plasma, frozen (-20°C/-4°F or below). (Minimum: 1.5 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate plasma from cells within 8 hours of collection. Transfer plasma to a plastic transport tube and freeze (-20°C/-4°F or below).

Transport: 4.0 mL serum or plasma, frozen (-20°C/-4°F or below). (Minimum:1.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-25°C or 68-77°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 72 hours
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Sunday – Saturday.
Results available in 3-4 days.

Reference Range

By report.

Test Methodology

Polymerase Chain Reaction/Sequencing.

Interpretation

Codons 457-630 of the UL97 gene and codons 393-1000 of the UL54 gene are sequenced. Mutations associated to ganciclovir, cidofovir, and foscarnet are reported. Mutations in sub-populations below 20 percent of total may not be detected.

NOTE: This test may be unsuccessful if the plasma CMV DNA viral load is less than 1,500 CMV DNA copies per mL of plasma.

CPT Codes

87910

Contacts

Last Updated

11/12/2020