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Pneumococcal Antibodies, IgG

Streptococcus Pneumoniae Antibodies, 23 Serotypes

Test Codes

Mayo: PN23, EPIC: LAB6129, Beaker: XPNAB

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.4 mL)

Rejection Criteria

• Hemolyzed specimens.
• Severely lipemic specimens.
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.4 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): unacceptable
Refrigerated (2-8°C or 36-46°F): 21 days
Frozen (-20°C/-4°F or below): 21 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Monday – Friday.
Results available in 5-7 days.

Reference Range

By report.

Test Methodology

Microsphere Photometry.

Interpretation

By report.

Clinical Utility

• Pneumococci have approximately 83 antigentically specific capsular polysaccharides that confer type-specific immunity. S. pneumoniae is the most common cause of otitis media and pneumonia is children less than 2 years old. Geriatric patients and those at high risk (cardiopulmonary and liver disease, recent splenectomy) are also susceptible to pneumococcal infections.
• The diagnosis and management of patients with chronic recurrent infections often requires an assessment of the patient's immune status. This includes evaluations for various immunoglobulins (IgG; IgG subclasses 1,2,3,and 4; IgA; IgM; and IgE) and tests of the patient's antibody-forming capacity when challenged with appropriate vaccines (diphtheria, tetanus, influenzae, polyvalent pneumococcal vaccine). Antibody concentrations can be used to determine the immune status of individuals previously immunized with the pneumococcal vaccine. A poor immune response to the pneumococcal-specific antigens may be indicative of a humoral immune defect.

CPT Codes

86317 x 22.
LOINC:  Type 4  86108-8, Type 9V  30153-1, Type 12F  85974-4, Type 18C  40913-6, Type 19F  86021-3, Type 23F  86061-9, Type 2  86039-5, Type 10A  86098-1, Type 11A  86122-9, Type 15B  40973-0, Type 17F  86009-8, Type 5  86130-2, Type 19A  40974-8, Type 20  86045-2, Type 22F  86052-8, Type 33F  40969-8, Type 6B  40905-2, Type 3  86081-7, Type 7F  40911-0,Type 9N  86166-6, Type 14  85992-6, Type 8  86148-4, Type 1  85954-6

Contacts

Last Updated

7/9/2021