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Tissue Transglutaminase (IgG)

Test Codes

Warde: TTGG, EPIC: LAB6163, Beaker: XTTGG

Specimen Collection Criteria

Collect: One Gold-top SST tube.

Also acceptable: One red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below). (Minimum: 0.5 mL)

Preparation for Courier Transport

Transport: 1.0 mL serum, frozen (-20°C/-4°F or below). (Minimum: 0.5 mL)

Rejection Criteria

Plasma specimens.

Severely hemolyzed or lipemic specimens. 

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below). (Minimum: 0.5 mL)

Transport: 1.0 mL serum, frozen (-20°C/-4°F or below). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 8  hours
Refrigerated (2-8°C or 36-46°F): 48 hours
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Warde Medical Laboratory, Ann Arbor, MI.

Performed

Monday – Friday.
Results available in 4-5 days

Reference Range

By report.

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA).

Interpretation

By report.

Clinical Utility

Tissue transglutaminase antibodies appear to be highly specific for celiac disease and are useful to screen high-risk populations (e.g. first degree relatives of celiac patients, insulin dependent diabetics, etc.) for celiac disease. However, histologic confirmation is required for diagnosis. Patients should not begin a gluten-free diet until after intestinal biopsy has been performed and the diagnosis is established. Serial tissue transglutaminase antibody testing may at times be useful to monitor dietary compliance.

CPT Codes

83516
LOINC:  32998-7

Contacts

Last Updated

7/15/2021