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Immunoglobulin D, Serum

IGD, IgD, Immune Competence

Test Codes

MAYO: IGD, EPIC: LAB6069, SOFT: XIGD

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Rejection Criteria

Grossly lipemic specimens.

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 21 days
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Monday – Saturday.
Results available in 2-4 days.

Reference Range

Less than or equal to 10 mg/dL.

Test Methodology

Nephelometry.

Interpretation

The physiologic significance of serum IgD concentration is unclear and in many normal persons serum IgD is undetectable.

Increased concentrations may be due to polyclonal (reactive) or monoclonal plasma cell proliferative processes.

A monoclonal IgD protein is present in 1% of patients with myeloma. Monoclonal IgD proteins are often in low concentrations and do not have a quantifiable M-peak on serum protein electrophoresis. However, the presence of an IgD monoclonal protein is almost always indicative of a malignant plasma cell disorder such as multiple myeloma or primary amyloidosis.

Clinical Utility

This assay aids in the diagnosis of IgD myeloma.

CPT Codes

82784
LOINC:  2460-4

Contacts

Last Updated

7/7/2021