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DPYD, 3 variants

DPD, Dihydropyrimidine Dehydrogenase, 5FU toxicity, Xeloda

Test Codes

Mayo: DPYDQ, EPIC: LAB7134, Beaker: XDPYD

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen):  One Lavender-top EDTA tube.

Physician Office/Draw Specimen Preparation

Do not centrifuge. Refrigerate (2-8°C or 36-46°F) specimens in original collection tube after collection.

Preparation for Courier Transport

Transport: 4.0 mL whole blood, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Rejection Criteria

• Frozen specimens.
• Specimens not collected and processed as indicated.

In-Lab Processing

Do not centrifuge. Refrigerate (2-8°C or 36-46°F) specimens in original collection tube after collection.

Transport: 4.0 mL whole blood, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 9 days
Refrigerated (2-8°C or 36-46°F): 30 days
Frozen (-20°C/-4°F or below): unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Monday – Friday
Results available in 4-11 days.

Reference Range

By report.

Test Methodology

Polymerase Chain Reaction and Allelic Discrimination Analysis.

Interpretation

By report.

Clinical Utility

This test is used to predict risk of dose-related toxicity to 5-FU therapy.

CPT Codes

81232
LOINC:  83009-1, 45284-7

Contacts

Last Updated

7/28/2021