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Ribosomal P Protein Antibody

Test Codes

Mayo: RIB, EPIC: LAB6145, Beaker: XRIBP

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.4 mL)

Rejection Criteria

Severely lipemic specimens.

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.4 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): unacceptable
Refrigerated (2-8°C or 36-46°F): 21 days
Frozen (-20°C/-4°F or below): 21 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Monday – Saturday.
Results available in 2-4 days.

Reference Range

By report.

Test Methodology

Multiplex Flow Immunoassay.

Clinical Utility

Autoantibodies reacting with cytoplasmic ribosomes are highly specific for systemic lupus erythematosus (SLE). Ribosomal P Antibodies are found in approximately 12% of patients with SLE and in 90% of patients with lupus psychosis; titers often increase more than five-fold during and before active phases of psychosis.

CPT Codes

83516
LOINC:  53892-6

Contacts

Last Updated

7/15/2021